Antioxidants in the (protein) fold
نویسندگان
چکیده
منابع مشابه
Clustering tendency in the protein fold space
Several non-redundant ensembles of protein three-dimensional structures were analyzed in order to estimate their natural clustering tendency by means of the Cox-Lewis coefficient. It was observed that, despite proteins tend to aggregate into different and well separated groups, some overlap between different clusters occurs. This suggests that classifications bases only on structural data canno...
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Proteins are susceptible to oxidation by reactive oxygen species, where the type of damage induced is characteristic of the denaturing species. The induction of protein carbonyls is a widely applied biomarker, arising from primary oxidative insult. However, when applied to complex biological and pathological conditions it can be subject to interference from lipid, carbohydrate and DNA oxidation...
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We have constructed, in a completely automated fashion, a new structure template library for threading that represents 358 distinct SCOP folds where each model is mathematically represented as a Hidden Markov model (HMM). Because the large number of models in the library can potentially dilute the prediction measure, a new triage method for fold prediction is employed. In the first step of the ...
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Structural biology of the PCI-protein fold
The PCI fold is based on a stack of α-helices topped with a winged-helix domain and is found in a range of proteins that form central parts of large complexes such as the proteasome lid, the COP9 signalosome, elongation factor eIF3, and the TREX-2 complex. Recent structural determinations have given intriguing insight into how these folds function both to facilitate the generation of larger pro...
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2008
ISSN: 1945-3477
DOI: 10.1038/scibx.2008.1037